Fri Sep 30 2022

30 articles - From Friday Sep 23 2022 to Friday Sep 30 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Rheum Dis

Deciphering the role of cDC2s in Sjögren's syndrome: transcriptomic profile links altered antigen processes with IFN signature and autoimmunity.

pSS cDC2s are transcriptionally altered, and the aberrant antigen uptake and processing, including (auto-)antigens, together with increased proliferation of tissue-homing CD4 + T cells, suggest altered antigen presentation by pSS cDC2s. These functional alterations were strongly linked to anti-SSA positivity and the presence of type I IFNs. Thus, we demonstrate novel molecular and functional pieces of evidence for the role of cDC2s in orchestrating immune response in pSS, which may yield novel avenues for treatment.

Pubmed   Journal   ReadQx 

Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies.

Background Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterised by myositis-related autoantibodies plus infiltration of leucocytes into muscles and/or the skin, leading to the destruction of blood vessels and muscle fibres, chronic weakness and fatigue. While complement-mediated destruction of capillary endothelia is implicated in paediatric and adult dermatomyositis, the complex diversity of complement contribute interactively to risk of polymyositis.

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Risk of major adverse cardiovascular events with tofacitinib versus tumour necrosis factor inhibitors in patients with rheumatoid arthritis with or without a history of atherosclerotic cardiovascular disease: a post hoc analysis from ORAL Surveillance.

This post hoc analysis observed higher MACE risk with tofacitinib versus TNFi in patients with RA and history of ASCVD. Among patients without history of ASCVD, al with prevalent CV risk factors, MACE risk did not appear different with tofacitinib 5 mg two times per day versus TNFi. Due to the exploratory nature of this analysis and low statistical power, we cannot exclude differential MACE risk for tofacitinib 5 mg two times per day versus TNFi among patients without history of ASCVD, but any absolute risk excess is likely low.

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Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis.

We also showed that Rspo2 orchestrated pathological crosstalk between synovial fibroblasts, macrophages and chondrocytes. Synovial fibroblasts assume distinct functional identities during PTOA in mice, and Prg4hi lining fibroblasts secrete Rspo2 that may drive pathological joint crosstalk after injury.

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Understanding sex-related differences in healthcare utilisation among patients with inflammatory arthritis: a population-based study.

Female patients with IA have higher healthcare utilisation than male patients which may indicate biological differences in disease course or sociocultural differences in healthcare-seeking behaviour.

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Venous thromboembolism with JAK inhibitors and other immune-modulatory drugs: a Swedish comparative safety study among patients with rheumatoid arthritis.

Patients with RA treated with JAKi in clinical practice are at increased risk of VTE compared with those treated with bDMARDs, an increase numerically confined to PE.

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Arthritis Care Res (Hoboken)

Influence of smoking on disease activity and quality of life in patients with rheumatoid arthritis: results from a Swedish case-control study with longitudinal follow-up.

Current smoking is associated with increased disease activity and lower health-related quality of life among RA patients. Smoking cessation within the first year after baseline seems to have a favourable effect on disease activity.

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Risk of COVID-19 among unvaccinated and vaccinated patients with rheumatoid arthritis: a general population study.

Patients with RA are still at higher risks of SARS-CoV-2 infection and COVID-19 hospitalization than the general population after receiving COVID-19 vaccines. These findings support booster COVID-19 vaccinations and adherence of other preventive strategies among patients with RA.

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Arthritis Res Ther

Dorso-ventral osteophytes of interphalangeal joints correlate with cartilage damage and synovial inflammation in hand osteoarthritis: a histological/radiographical study.

dvOPs are associated with increasing structural alterations in DIP and PIP joints and can be seen as markers of advanced joint damage. Detecting dvOPs can facilitate the diagnosis process and improve damage estimation in HOA.

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Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype.

We found biologically relevant differences in gene expression between JIA subtypes that support a critical role for FLS in pathogenesis. We also demonstrate that gene expression within the chondrocyte-like subpopulation can be used to distinguish between these subtypes.

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Rheumatology (Oxford)

A novel long noncoding RNA, lnc-RNU12, influences the T-cell cycle via c-JUN and CCNL2 in rheumatoid arthritis.

Our study suggested that lnc-RNU12 was involved in the pathogenesis of RA by influencing the T cell cycle by targeting c-JUN and CCNL2.

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Association of mycophenolate and azathioprine use with cognitive function in systemic lupus.

AZA use was associated with significantly lower odds of SLE-CD, while MMF use was not. Additional studies are warranted to further investigate the relationship of AZA and SLE-CD.

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Brodalumab, an anti-interleukin-17 receptor A monoclonal antibody, in axial spondyloarthritis: 68-week results from a phase 3 study.

Brodalumab demonstrated sustained efficacy and a consistent safety profile in patients with axSpA over 68weeks. Clinical trial registration

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Continuing specialist care into adulthood in young people with juvenile idiopathic arthritis: a retrospective cohort study using electronic health records in England.

Two-thirds of young people with JIA continue to receive specialist care beyond age 18. This is useful information for children and young people with JIA and their families planning for their future, and for clinicians planning healthcare services.

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Development of prediction models to select older RA patients with comorbidities for treatment with chronic low-dose glucocorticoids.

Baseline factors are not helpful to select elderly RA patients for treatment with low-dose prednisolone given their low power to predict the chance of benefit or harm.

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Eosinophilic fasciitis (Shulman syndrome) - recognition of the histological spectrum allows for new insights into possible pathomechanisms.

Our findings highlight a specific immune phenotype of leucocyte infiltrates in EF along features of perifascicular pathology similar to DM, while there is no evidence of hypoxia-mediated or type I Interferon associated processes with perifascicular fibre atrophy, indicating different pathomechanisms of muscle involvement.

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Improved Sensitivity of Skin Pathergy Test with Polysaccharide Pneumococcal Vaccine Antigens in the Diagnosis of Behçet Disease.

SPT induced by 20G needle-prick and PS-23 antigens was shown to be a promising tool for the diagnosis of BD owing to its improved sensitivity compared with the standard applications.

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Longitudinal study of patients with antimelanoma differentiation-associated gene 5 antibody-positive dermatomyositis associated interstitial lung disease.

MDA5+ DM-ILD patients had a high mortality rate despite aggressive treatment. Patients who survived the first year usually showed a significant improvement in serological markers and pulmonary function during the long-term follow-up.

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Systemic Sclerosis Associated Interstitial Lung Disease: A Conceptual Framework for Subclinical, Clinical, and Progressive Disease.

Using our proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression, and progression over time. Experts rely on similar items when classifying disease severity and progression a combination of spirometry and gas exchange and quantitative HRCT.

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Whole grain consumption and risk of radiographic knee osteoarthritis: a prospective study from the Osteoarthritis Initiative.

Our findings revealed a significant inverse association of whole-grain consumption with knee OA risk. These findings provide evidence that eating a diet rich in whole grains may be a potential nutritional strategy to prevent knee OA.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Rheum Dis

From real-world electronic health record data to real-world results using artificial intelligence.

In summary, EHR data represent a rapidly growing and key resource for real-world studies. However, transforming RWD EHR data for research and for real-world evidence using ML requires knowledge of the EHR system and their differences from existing observational data to ensure that studies incorporate rigorous methods that acknowledge or address factors such as access to care, noise in the data, missingness and indication bias.

Pubmed   Journal   ReadQx 

Arthritis Rheumatol

I Kappa B-Kliev-E that the inhibitor of nuclear factor kappa-B kinase epsilon (IKBKE) may hold the key to treating NP-SLE!

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Rheum Dis

Tumorous calcinosis of the atlantoaxial joint: the helmeted dens syndrome.

Pubmed   Journal   ReadQx 

Arthritis Care Res (Hoboken)

A 58-Year-Old Man Presenting with Joint Pain and Confusion.

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Arthritis Rheumatol

Overturning Roe v. Wade: Toppling the Practice of Rheumatology.

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Supporting International Medical Graduates in Rheumatology: A call to action.

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Rheumatology (Oxford)

Comment on: Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen.

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Comment on: Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen: reply.

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PET/CT in giant cell arteritis: will the best imaging technique please stand up?

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The clinical impact of systemic sclerosis-related calcinosis-results of a patient survey.

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Letters&Replies

Letters to the editors and authors’ replies